Meta Information
ID:noopept
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/cholinesterase-inhibitors
Target name:
Cholinesterase Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Noopept sensitizes acetylcholine receptors while cholinesterase inhibitors (e.g., Donepezil, Huperzine A) increase acetylcholine levels. This combination can lead to an excessive cholinergic state, potentially causing severe side effects like nausea, bradycardia, and salivation.
Actionable advice:
Avoid combining Noopept with any cholinesterase inhibitors unless under strict medical supervision.
Target id:
/condition/hepatic-impairment
Target name:
Liver Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The metabolism and safety of Noopept have not been studied in individuals with significant liver disease. Its use is contraindicated due to unpredictable effects on drug clearance and potential for toxicity.
Actionable advice:
Do not use Noopept if you have been diagnosed with moderate to severe liver impairment.
Target id:
/condition/renal-impairment
Target name:
Kidney Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The clearance and safety of Noopept have not been studied in individuals with significant kidney disease. Its use is contraindicated due to unpredictable effects and potential for accumulation.
Actionable advice:
Do not use Noopept if you have been diagnosed with moderate to severe kidney impairment.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The effects of Noopept on fetal development are unknown. Due to the complete lack of safety data, it is strictly contraindicated during pregnancy.
Actionable advice:
Avoid using Noopept completely if you are pregnant or planning to become pregnant.
Target id:
/condition/lactation
Target name:
Breastfeeding
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is not known if Noopept or its metabolites are excreted in breast milk or what their effects on a nursing infant might be. Due to the lack of safety data, it is strictly contraindicated.
Actionable advice:
Avoid using Noopept completely if you are breastfeeding.
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
By modulating key neurotransmitter systems like glutamate, Noopept could potentially destabilize mood and trigger manic or depressive episodes in individuals with bipolar disorder.
Actionable advice:
Avoid Noopept if you have a history of bipolar disorder or other severe psychiatric conditions.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
2
Description:
Taking Noopept with food, particularly protein-rich meals, may reduce its absorption and bioavailability as it can compete with dietary amino acids and peptides in the gut.
Actionable advice:
Take Noopept on an empty stomach, at least 30 minutes before a meal or 2 hours after eating.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
6
Hours after target:
null
Description:
Due to its potential stimulating effects on neurotransmitter systems like glutamate and acetylcholine, taking Noopept late in the day may interfere with your ability to fall asleep or reduce sleep quality.
Actionable advice:
Take your last dose of Noopept at least 6 hours before your planned bedtime.
Target id:
/class/anticholinergic-medications
Target name:
Anticholinergic Medications
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Noopept works by enhancing the acetylcholine system, while anticholinergic medications (e.g., diphenhydramine, certain antidepressants) work by blocking it. Taking them together may reduce the effectiveness of both substances.
Actionable advice:
Avoid co-administration with medications that have strong anticholinergic properties, as they may counteract Noopept's benefits.
Target id:
/class/stimulants
Target name:
Stimulant Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining Noopept with other central nervous system stimulants (e.g., caffeine, amphetamines, modafinil) can have an additive effect, potentially causing overstimulation, anxiety, jitteriness, or insomnia.
Actionable advice:
Use caution when combining with other stimulants; start with very low doses of each to assess tolerance.
Target id:
/dietary/alcohol-acute
Target name:
Alcohol
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Alcohol is a central nervous system depressant that can counteract the cognitive-enhancing effects of Noopept. The combined effects on the brain are unpredictable and should be avoided.
Actionable advice:
Avoid consuming alcohol while using Noopept to preserve its cognitive benefits and prevent unpredictable interactions.
Target id:
/condition/hypertension
Target name:
Hypertension
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The effects of Noopept on blood pressure can be unpredictable. In individuals with pre-existing or poorly controlled hypertension, it could potentially cause elevations in blood pressure.
Actionable advice:
Avoid Noopept if you have severe or uncontrolled hypertension, and consult a physician if your hypertension is managed.
Target id:
/class/choline-precursors
Target name:
Choline Precursors
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Noopept enhances the brain's use of acetylcholine. Taking a choline source (e.g., Alpha-GPC, Citicoline) provides the raw material to produce more acetylcholine, potentially enhancing effects and preventing headaches from choline depletion.
Actionable advice:
Consider taking Noopept with a choline source to support cognitive effects and reduce the risk of headaches.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Noopept may have a mild blood pressure-lowering effect in some individuals. Combining it with antihypertensive medications could theoretically lead to an additive effect, increasing the risk of hypotension (low blood pressure).
Actionable advice:
If you take blood pressure medication, monitor your blood pressure when starting Noopept and consult your doctor.