MSM (Methylsulfonylmethane)

MSM is an organosulfur compound that provides a bioavailable source of sulfur. This is critical for synthesizing the master antioxidant glutathione and for maintaining the integrity of connective tissues like cartilage. Its primary healthspan relevance lies in its potential to reduce chronic inflammation and oxidative stress, key drivers of aging, particularly in the context of joint and skin health.

Verdict

A safe, low-cost supplement for joint health and inflammation.

Protocol

• Take 1-6 grams daily, often split into multiple doses to improve tolerance.

Flags

• May cause mild gastrointestinal issues like bloating or diarrhea at higher doses.
• Theoretically may have a mild blood-thinning effect; use with caution if on anticoagulants.
• Supplement quality can vary; seek products with third-party purity testing.