← Back to Directory

MSM (Methylsulfonylmethane)

Dimethyl sulfone, DMSO2

Visual ViewRaw DataInteraction Data

Meta Information

ID:msm
Name:MSM (Methylsulfonylmethane)
Schema Version:1.5

Alternate Names

  • Dimethyl sulfone
  • DMSO2

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
5
High Cost:
20
Cost Type:
monthly
Description:
Widely available and inexpensive over-the-counter supplement.

Summary

MSM is an organosulfur compound that provides a bioavailable source of sulfur. This is critical for synthesizing the master antioxidant glutathione and for maintaining the integrity of connective tissues like cartilage. Its primary healthspan relevance lies in its potential to reduce chronic inflammation and oxidative stress, key drivers of aging, particularly in the context of joint and skin health.

Purpose

Provides sulfur to reduce inflammation and support connective tissue.

Card Summary

An organosulfur compound that provides a bioavailable source of sulfur, critical for synthesizing the master antioxidant glutathione and for maintaining the integrity of connective tissues like cartilage.

Drug Class

Drugs In Class

Empty Array

Impact

Score:
4.5
Justification:
Targets inflammation and oxidative stress, primarily benefiting joint and skin health.

Evidence

Grade:
B
Score:
6.5
Justification:
Human RCTs exist for specific conditions like osteoarthritis, but not for broad longevity.

Safety

Score:
2.5
Justification:
Generally Recognized as Safe (GRAS) status with mild, infrequent gastrointestinal side effects.

Flags

  • May cause mild gastrointestinal issues like bloating or diarrhea at higher doses.
  • Theoretically may have a mild blood-thinning effect; use with caution if on anticoagulants.
  • Supplement quality can vary; seek products with third-party purity testing.

Verdict

A safe, low-cost supplement for joint health and inflammation.

Created

2026-04-26T18:15:49.680038Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
MSM is an organosulfur compound that provides a bioavailable source of sulfur. This is critical for synthesizing the master antioxidant glutathione and for maintaining the integrity of connective tiss...

Typical Protocol

  • Take 1-6 grams daily, often split into multiple doses to improve tolerance.