MOTS-c is a peptide encoded within the mitochondrial genome that plays a key role in metabolic homeostasis. It appears to mimic some effects of exercise by activating the AMPK pathway, thereby improving glucose utilization, insulin sensitivity, and cellular energy regulation. Its relevance to longevity stems from its potential to restore youthful mitochondrial function and combat age-related metabolic dysfunction, such as sarcopenia and insulin resistance.
Verdict
A promising but highly experimental peptide for metabolic health.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
High
EVIDENCE GRADE
C
MONTHLY COST
$600 - $1200
Protocol
- 10mg injected subcutaneously 3 times per week for cycles of 4-8 weeks.
Flags
- Not approved for human use by the FDA.
- Sourced from unregulated research chemical suppliers, raising purity and safety concerns.
- Long-term side effects in humans are unknown.
- Potential for mitogenic effects requires caution, especially with a history of cancer.