Meta Information

ID:mots-c

Name:MOTS-c

Schema Version:1.5

Alternate Names

• Mitochondrial-derived peptide

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

600

High Cost:

1200

Cost Type:

monthly

Description:

Cost for research-grade peptide from third-party suppliers.

Summary

MOTS-c is a peptide encoded within the mitochondrial genome that plays a key role in metabolic homeostasis. It appears to mimic some effects of exercise by activating the AMPK pathway, thereby improving glucose utilization, insulin sensitivity, and cellular energy regulation. Its relevance to longevity stems from its potential to restore youthful mitochondrial function and combat age-related metabolic dysfunction, such as sarcopenia and insulin resistance.

Purpose

Mitochondrial-derived peptide that enhances metabolic function and mimics exercise.

Card Summary

A mitochondrial-derived peptide that regulates metabolism and insulin sensitivity, mimicking some effects of exercise.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

5.5

Justification:

Potentially powerful metabolic and mitochondrial regulator, but human longevity data is lacking.

Evidence

Grade:

C

Score:

3.5

Justification:

Strong pre-clinical and animal data, but very limited human trial evidence.

Safety

Score:

7.5

Justification:

Unregulated research chemical with no long-term human safety data; purity is a concern.

Flags

• Not approved for human use by the FDA.
• Sourced from unregulated research chemical suppliers, raising purity and safety concerns.
• Long-term side effects in humans are unknown.
• Potential for mitogenic effects requires caution, especially with a history of cancer.

Verdict

A promising but highly experimental peptide for metabolic health.

Created

2026-04-25T01:11:44.326683Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

subcutaneous_injection

Scope:

• systemic

Indication

Focus:

healthspan

Description:

MOTS-c is a peptide encoded within the mitochondrial genome that plays a key role in metabolic homeostasis. It appears to mimic some effects of exercise by activating the AMPK pathway, thereby improvi...

Typical Protocol

• 10mg injected subcutaneously 3 times per week for cycles of 4-8 weeks.