Methylene Blue acts as an electron cycler in the mitochondrial electron transport chain, which can enhance ATP production and cellular respiration under certain conditions. Its relevance to longevity stems from its potential to improve mitochondrial efficiency and offer neuroprotective effects, though human healthspan data is currently lacking.
Verdict
A high-risk, experimental mitochondrial enhancer requiring extreme caution and medical guidance.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
High
EVIDENCE GRADE
C
MONTHLY COST
$5 - $20
Protocol
- Microdosing at 0.5mg to 4mg daily is a common protocol for mitochondrial support.
- Cycling, such as 5 days on and 2 days off, is often employed.
Flags
- Contraindicated with SSRI/SNRI antidepressants due to high risk of fatal serotonin syndrome.
- Must be USP grade; industrial grades contain dangerous heavy metal contaminants.
- Acts as a monoamine oxidase inhibitor (MAOI), requiring significant drug and dietary precautions.
- Not recommended for individuals with G6PD deficiency due to risk of hemolysis.
- Will turn urine and other bodily fluids blue, which is harmless but notable.