Meta Information

ID:methylene-blue

Name:Methylene Blue

Schema Version:1.5

Title

Methylene Blue

Alternate Names

• MB
• Methylthioninium chloride

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

20

Cost Type:

monthly

Description:

Cost for USP-grade liquid concentrate or powder forms at typical microdoses.

Summary

Methylene Blue acts as an electron cycler in the mitochondrial electron transport chain, which can enhance ATP production and cellular respiration under certain conditions. Its relevance to longevity stems from its potential to improve mitochondrial efficiency and offer neuroprotective effects, though human healthspan data is currently lacking.

Purpose

Enhances mitochondrial function and cellular energy production.

Card Summary

A mitochondrial enhancer that improves cellular energy production and may offer neuroprotective benefits.

Drug Class

monoamine-oxidase-inhibitor

Drugs In Class

Empty Array

Impact

Score:

4.2

Justification:

Theoretically potent mitochondrial enhancer, but lacks human longevity or healthspan trial data.

Evidence

Grade:

C

Score:

3.5

Justification:

Primarily supported by in-vitro and animal studies for longevity-related mechanisms.

Safety

Score:

6.8

Justification:

High risk of serotonin syndrome when combined with common antidepressant medications (SSRIs/SNRIs).

Flags

• Contraindicated with SSRI/SNRI antidepressants due to high risk of fatal serotonin syndrome.
• Must be USP grade; industrial grades contain dangerous heavy metal contaminants.
• Acts as a monoamine oxidase inhibitor (MAOI), requiring significant drug and dietary precautions.
• Not recommended for individuals with G6PD deficiency due to risk of hemolysis.
• Will turn urine and other bodily fluids blue, which is harmless but notable.

Verdict

A high-risk, experimental mitochondrial enhancer requiring extreme caution and medical guidance.

Created

2026-04-23T23:45:23.363960Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

Methylene Blue acts as an electron cycler in the mitochondrial electron transport chain, which can enhance ATP production and cellular respiration under certain conditions. Its relevance to longevity ...

Typical Protocol

• Microdosing at 0.5mg to 4mg daily is a common protocol for mitochondrial support.
• Cycling, such as 5 days on and 2 days off, is often employed.