Meta Information
ID:magnesium
Name:Magnesium
Schema Version:1.5
Title
Magnesium
Alternate Names
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium L-Threonate
- Magnesium Oxide
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
5
High Cost:
30
Cost Type:
monthly
Description:
Cost for daily oral supplementation using common, bioavailable forms.
Summary
Magnesium is an essential mineral and a cofactor in over 300 enzymatic systems, including those for ATP synthesis, DNA/RNA repair, and glucose metabolism. From a healthspan perspective, maintaining optimal magnesium levels is crucial for preserving mitochondrial function, reducing chronic inflammation, supporting cardiovascular health, and maintaining insulin sensitivity, all of which decline with age.
Purpose
Essential mineral cofactor for energy, DNA repair, and metabolic health.
Card Summary
An essential mineral involved in over 300 critical enzymatic reactions, supporting energy production, DNA stability, and metabolic health. Widespread deficiency makes supplementation a high-leverage intervention for many.
Drug Class
Drugs In Class
- magnesium-citrate
- magnesium-glycinate
- magnesium-l-threonate
- magnesium-malate
- magnesium-taurate
- magnesium-chloride
- magnesium-supplementation
Impact
Score:
7.8
Justification:
Corrects common deficiencies; crucial for ATP production, DNA repair, and insulin sensitivity.
Evidence
Grade:
A
Score:
9
Justification:
Extensive human observational data and RCTs link magnesium to major health outcomes.
Safety
Score:
2.5
Justification:
Generally Recognized As Safe (GRAS); primary side effect is self-limiting gastrointestinal distress.
Flags
- Excessive doses can cause diarrhea, especially with less bioavailable forms like oxide.
- Individuals with kidney disease should consult a physician before supplementing.
- Can interfere with the absorption of certain antibiotics and bisphosphonates.
Verdict
A foundational, safe, and low-cost intervention for metabolic and cellular health.
Qualifier
(mineral, not a specific formulation)
Created
2026-04-23T23:42:43.953653Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Magnesium is an essential mineral and a cofactor in over 300 enzymatic systems, including those for ATP synthesis, DNA/RNA repair, and glucose metabolism. From a healthspan perspective, maintaining op...
Typical Protocol
- Daily supplementation of 200-500mg of elemental magnesium from a bioavailable form like glycinate or citrate.