Meta Information
ID:magnesium-taurate
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/chelating-antibiotics
Target name:
Chelating Antibiotics (Tetracyclines, Quinolones)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
4
Description:
Magnesium binds to tetracycline and fluoroquinolone antibiotics in the gut, forming an insoluble complex that prevents their absorption and severely reduces their effectiveness.
Actionable advice:
Take magnesium at least 2 hours before or 4 hours after these antibiotics.
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Magnesium forms a complex with bisphosphonate drugs (e.g., alendronate for osteoporosis), significantly reducing their absorption from the intestine.
Actionable advice:
Separate doses of magnesium and bisphosphonates by at least 2 hours.
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The kidneys are responsible for excreting excess magnesium. Impaired kidney function can lead to a toxic accumulation of magnesium in the blood (hypermagnesemia).
Actionable advice:
Avoid magnesium supplements unless specifically prescribed and monitored by a physician.
Target id:
/class/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Chronic use of PPIs can severely impair the intestinal absorption of magnesium, leading to clinically significant hypomagnesemia over months or years.
Actionable advice:
If on long-term PPI therapy, monitor magnesium levels regularly and consider supplementation under medical guidance.
Target id:
/condition/myasthenia-gravis
Target name:
Myasthenia Gravis
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Magnesium can inhibit the release of acetylcholine at the neuromuscular junction, which can worsen muscle weakness in individuals with myasthenia gravis.
Actionable advice:
Avoid magnesium supplementation completely.
Target id:
/condition/heart-block
Target name:
Heart Block (AV Block)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High levels of magnesium can slow electrical conduction in the heart, potentially worsening atrioventricular (AV) block.
Actionable advice:
Avoid magnesium supplements unless approved and monitored by a cardiologist.
Target id:
/class/thyroid-hormones
Target name:
Thyroid Hormones
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
Magnesium can bind to thyroid hormones like levothyroxine in the gut, impairing their absorption and potentially leading to reduced efficacy.
Actionable advice:
Separate doses of magnesium and thyroid medication by at least 4 hours.
Target id:
/class/calcium-supplements
Target name:
Calcium Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of calcium and magnesium compete for the same absorption pathways in the intestine, reducing the absorption of both minerals.
Actionable advice:
Separate high-dose calcium and magnesium supplements by at least 2 hours.
Target id:
/intervention/iron-supplements
Target name:
Iron Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Magnesium can interfere with the absorption of non-heme iron supplements when taken at the same time.
Actionable advice:
Separate magnesium and iron supplements by at least 2 hours.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Magnesium and taurine both promote vasodilation and can lower blood pressure, potentially enhancing the effects of antihypertensive medications and increasing the risk of hypotension.
Actionable advice:
Monitor blood pressure closely when combining; dose adjustments of medication may be needed.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Both magnesium and taurine can improve insulin sensitivity and lower blood glucose, which may potentiate the effects of diabetes medications and increase the risk of hypoglycemia.
Actionable advice:
Monitor blood glucose levels carefully when starting magnesium taurate.
Target id:
/class/potassium-sparing-diuretics
Target name:
Potassium-Sparing Diuretics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
These diuretics (e.g., spironolactone, amiloride) can reduce the excretion of magnesium, increasing the risk of hypermagnesemia (high magnesium levels) when taken with supplements.
Actionable advice:
Avoid high-dose magnesium supplements unless under medical supervision.
Target id:
/class/loop-diuretics
Target name:
Loop Diuretics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Loop diuretics (e.g., furosemide) increase the urinary excretion of magnesium, which can lead to magnesium deficiency over time.
Actionable advice:
Regular monitoring of magnesium levels is recommended; supplementation may be necessary.
Target id:
/class/thiazide-diuretics
Target name:
Thiazide Diuretics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Long-term use of thiazide diuretics (e.g., hydrochlorothiazide) can increase magnesium loss through the kidneys, potentially causing depletion.
Actionable advice:
Monitor magnesium status if using these medications long-term.
Target id:
/intervention/vitamin-d
Target name:
Vitamin D
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Magnesium is a required cofactor for the activation and metabolism of Vitamin D in the liver and kidneys. Adequate magnesium levels are necessary for Vitamin D to function properly.
Actionable advice:
Ensure adequate magnesium intake when supplementing with Vitamin D to support its efficacy.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
null
Description:
Both magnesium and taurine promote relaxation and support GABAergic neurotransmission, which can improve sleep onset and quality.
Actionable advice:
Take 30-60 minutes before bedtime to support sleep.
Target id:
/class/cns-depressants
Target name:
CNS Depressants
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
The taurine component has GABAergic effects and magnesium can have a calming effect, potentially leading to additive drowsiness or sedation when combined with other CNS depressants like benzodiazepines or alcohol.
Actionable advice:
Use with caution and be aware of potential for increased drowsiness.
Target id:
/intervention/zinc
Target name:
Zinc
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Very high doses of zinc can impair magnesium absorption, and vice-versa, due to competition for intestinal transporters.
Actionable advice:
For optimal absorption, separate high-dose zinc and magnesium supplements by at least 2 hours.
Target id:
/dietary/phytate-rich-foods
Target name:
Phytate-Rich Foods (Grains, Legumes, Nuts)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
1
Description:
Phytates found in whole grains, legumes, and nuts can bind to magnesium in the gut, forming an insoluble salt and reducing its absorption.
Actionable advice:
Take magnesium at least 1 hour away from meals very high in phytates for best absorption.
Target id:
/dietary/oxalate-rich-foods
Target name:
Oxalate-Rich Foods (Spinach, Rhubarb, Beets)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
1
Description:
Oxalates, present in foods like spinach and rhubarb, can bind with magnesium to form insoluble magnesium oxalate, which is poorly absorbed.
Actionable advice:
Take magnesium at least 1 hour away from meals very high in oxalates.
Target id:
/intervention/vitamin-b6
Target name:
Vitamin B6
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin B6 (in its P5P form) is a cofactor that facilitates the transport of magnesium into cells, potentially enhancing its intracellular effectiveness.
Actionable advice:
Consider taking with a B-complex or a small dose of Vitamin B6 (P5P).
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
2
Description:
Taking magnesium with food can reduce gastrointestinal side effects, but may slightly decrease overall absorption due to binding with fiber and other compounds.
Actionable advice:
For maximum absorption, take on an empty stomach; if GI upset occurs, take with a small meal.