Lycopene is a potent carotenoid antioxidant, abundant in tomatoes and other red-hued produce. Its primary mechanism involves neutralizing reactive oxygen species (ROS), thereby mitigating cellular damage from oxidative stress, a key driver of aging. From a healthspan perspective, it is primarily investigated for its potential to support cardiovascular health by improving endothelial function and reducing LDL oxidation, as well as protecting skin from UV-induced damage.
Verdict
A safe, targeted antioxidant, but dietary sources may be sufficient.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$5 - $15
Protocol
- Daily supplementation of 10-30 mg, often taken with a source of fat for better absorption.
Flags
- Best absorbed when consumed with dietary fats.
- May interact with blood thinners (anticoagulants) and blood pressure medications.
- Extremely high doses can cause a harmless orange discoloration of the skin (lycopenodermia).
- Smokers should exercise caution with high-dose isolated carotenoid supplements.