Meta Information

ID:lycopene

Name:Lycopene

Schema Version:1.5

Alternate Names

• psi-psi-carotene

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

15

Cost Type:

monthly

Description:

Widely available over-the-counter supplement; not covered by insurance.

Summary

Lycopene is a potent carotenoid antioxidant, abundant in tomatoes and other red-hued produce. Its primary mechanism involves neutralizing reactive oxygen species (ROS), thereby mitigating cellular damage from oxidative stress, a key driver of aging. From a healthspan perspective, it is primarily investigated for its potential to support cardiovascular health by improving endothelial function and reducing LDL oxidation, as well as protecting skin from UV-induced damage.

Purpose

A potent antioxidant carotenoid for cellular protection and cardiovascular support.

Card Summary

A potent antioxidant found in tomatoes, studied for reducing oxidative stress, supporting cardiovascular health, and protecting skin.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Offers targeted antioxidant benefits, particularly for cardiovascular and skin health, but lacks broad systemic effects.

Evidence

Grade:

B

Score:

6.5

Justification:

Human trials and meta-analyses exist but show modest or inconsistent effects on major endpoints.

Safety

Score:

2.5

Justification:

Generally recognized as safe (GRAS) with a high safety threshold; found in common foods.

Flags

• Best absorbed when consumed with dietary fats.
• May interact with blood thinners (anticoagulants) and blood pressure medications.
• Extremely high doses can cause a harmless orange discoloration of the skin (lycopenodermia).
• Smokers should exercise caution with high-dose isolated carotenoid supplements.

Verdict

A safe, targeted antioxidant, but dietary sources may be sufficient.

Created

2026-04-26T17:38:39.825563Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Lycopene is a potent carotenoid antioxidant, abundant in tomatoes and other red-hued produce. Its primary mechanism involves neutralizing reactive oxygen species (ROS), thereby mitigating cellular dam...

Typical Protocol

• Daily supplementation of 10-30 mg, often taken with a source of fat for better absorption.