Low Dose Naltrexone (LDN) transiently blocks opioid receptors, leading to an upregulation of endorphins and enkephalins. This rebound effect is believed to modulate the immune system, reduce neuroinflammation, and normalize inflammatory responses. Its primary relevance to healthspan is its potential to mitigate chronic, low-grade inflammation (inflammaging), a key driver of many age-related diseases.
Verdict
A promising anti-inflammatory tool, but direct evidence for longevity is lacking.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
C
MONTHLY COST
$30 - $60
Protocol
- Titrate from 1.5mg up to 4.5mg, taken once daily, typically at bedtime.
Flags
- Requires a prescription and must be obtained from a compounding pharmacy.
- Contraindicated for individuals taking opioid pain medications due to blocking effects.
- May cause initial sleep disturbances or vivid dreams, which often resolve.
- Use with caution in patients with liver disease or those taking immunosuppressants.