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Low Dose Naltrexone (LDN)

LDN

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Meta Information

ID:low-dose-naltrexone
Name:Low Dose Naltrexone (LDN)
Schema Version:1.5

Title

Low Dose Naltrexone

Alternate Names

  • LDN

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
30
High Cost:
60
Cost Type:
monthly
Description:
Requires a prescription and is sourced from a compounding pharmacy.

Summary

Low Dose Naltrexone (LDN) transiently blocks opioid receptors, leading to an upregulation of endorphins and enkephalins. This rebound effect is believed to modulate the immune system, reduce neuroinflammation, and normalize inflammatory responses. Its primary relevance to healthspan is its potential to mitigate chronic, low-grade inflammation (inflammaging), a key driver of many age-related diseases.

Purpose

Reduces chronic inflammation by modulating the immune system.

Card Summary

An opioid antagonist used at very low doses to modulate the immune system, reduce chronic inflammation, and potentially improve autoimmune conditions.

Drug Class

opioid-antagonist

Drugs In Class

Empty Array

Impact

Score:
4.5
Justification:
Targets chronic inflammation, a key pillar of aging, but lacks direct longevity data.

Evidence

Grade:
C
Score:
3.5
Justification:
Human trials exist for specific diseases, but not for general healthspan or longevity.

Safety

Score:
4.2
Justification:
Generally well-tolerated with mild side effects, but requires a prescription and monitoring.

Flags

  • Requires a prescription and must be obtained from a compounding pharmacy.
  • Contraindicated for individuals taking opioid pain medications due to blocking effects.
  • May cause initial sleep disturbances or vivid dreams, which often resolve.
  • Use with caution in patients with liver disease or those taking immunosuppressants.

Verdict

A promising anti-inflammatory tool, but direct evidence for longevity is lacking.

Created

2026-04-23T23:41:29.088598Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
Low Dose Naltrexone (LDN) transiently blocks opioid receptors, leading to an upregulation of endorphins and enkephalins. This rebound effect is believed to modulate the immune system, reduce neuroinfl...

Typical Protocol

  • Titrate from 1.5mg up to 4.5mg, taken once daily, typically at bedtime.