Lithium is a trace element that inhibits the enzyme GSK-3, a key regulator in cellular aging, inflammation, and nutrient sensing pathways. Epidemiological data links higher levels of naturally occurring lithium in drinking water with increased longevity and reduced all-cause mortality, suggesting a potential role in promoting healthspan at microdoses.
Verdict
Promising based on population data, but direct evidence for longevity is limited.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$3 - $8
Protocol
- Daily doses of 1-5mg of elemental lithium are common for healthspan purposes.
Flags
- Microdoses are distinct from high-dose prescription lithium carbonate used for bipolar disorder.
- High doses can impact thyroid and kidney function; long-term microdosing safety is not fully established.
- Interacts with diuretics, NSAIDs, and ACE inhibitors, potentially increasing lithium levels.