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Lithium Orotate

Microdose Lithium, Elemental Lithium

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Meta Information

ID:lithium
Name:Lithium Orotate
Schema Version:1.5

Title

Lithium Orotate

Alternate Names

  • Microdose Lithium
  • Elemental Lithium

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
3
High Cost:
8
Cost Type:
monthly
Description:
Widely available as an inexpensive over-the-counter dietary supplement.

Summary

Lithium is a trace element that inhibits the enzyme GSK-3, a key regulator in cellular aging, inflammation, and nutrient sensing pathways. Epidemiological data links higher levels of naturally occurring lithium in drinking water with increased longevity and reduced all-cause mortality, suggesting a potential role in promoting healthspan at microdoses.

Purpose

A trace mineral that may support brain health and longevity pathways.

Card Summary

A trace mineral and GSK-3 inhibitor that may support brain health, mood stability, and cellular longevity pathways at microdoses.

Drug Class

Drugs In Class

  • lithium-microdose
  • lithium-carbonate
  • lithium-orotate

Impact

Score:
3.5
Justification:
Primarily based on epidemiological data and animal models; lacks human longevity RCTs.

Evidence

Grade:
B
Score:
4.5
Justification:
Strong epidemiological correlations and mechanistic animal data, but lacks direct human longevity trials.

Safety

Score:
2.5
Justification:
Very low doses are distinct from high-dose prescription forms and have a high safety profile.

Flags

  • Microdoses are distinct from high-dose prescription lithium carbonate used for bipolar disorder.
  • High doses can impact thyroid and kidney function; long-term microdosing safety is not fully established.
  • Interacts with diuretics, NSAIDs, and ACE inhibitors, potentially increasing lithium levels.

Verdict

Promising based on population data, but direct evidence for longevity is limited.

Created

2026-04-23T23:41:14.662177Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
Lithium is a trace element that inhibits the enzyme GSK-3, a key regulator in cellular aging, inflammation, and nutrient sensing pathways. Epidemiological data links higher levels of naturally occurri...

Typical Protocol

  • Daily doses of 1-5mg of elemental lithium are common for healthspan purposes.