Lisinopril is an Angiotensin-Converting Enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action lowers blood pressure, reduces cardiac workload, and offers renoprotective effects. By effectively managing hypertension, Lisinopril significantly reduces the risk of cardiovascular events, stroke, and kidney disease, thereby extending healthspan and reducing age-related morbidity.
Verdict
Effective for hypertension; critical for cardiovascular and kidney health.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$5 - $30
Protocol
- Commonly prescribed dosages for hypertension range from 5 mg to 40 mg once daily, titrated to achieve optimal blood pressure control, which is crucial for long-term cardiovascular and renal health.
Flags
- Risk of persistent dry cough, a common side effect.
- Potential for angioedema (swelling of face, lips, tongue, throat), a rare but serious adverse event.
- May cause hyperkalemia (high potassium levels), especially with potassium supplements or diuretics.
- Risk of acute kidney injury, particularly in individuals with pre-existing renal impairment or dehydration.
- Contraindicated in pregnancy due to risk of fetal harm.
- Interacts with NSAIDs, lithium, and potassium-sparing diuretics.
- May cause symptomatic hypotension, especially with initial doses or in volume-depleted patients.