Meta Information

ID:lisinopril

Name:Lisinopril

Schema Version:1.5

Alternate Names

• Prinivil
• Zestril

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

30

Cost Type:

monthly

Description:

Low-cost generic, often covered by insurance for hypertension management.

Summary

Lisinopril is an Angiotensin-Converting Enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action lowers blood pressure, reduces cardiac workload, and offers renoprotective effects. By effectively managing hypertension, Lisinopril significantly reduces the risk of cardiovascular events, stroke, and kidney disease, thereby extending healthspan and reducing age-related morbidity.

Purpose

Manages hypertension to reduce cardiovascular and renal disease risk.

Card Summary

ACE inhibitor for blood pressure control, reducing cardiovascular and kidney disease risk.

Drug Class

ACE Inhibitor

Drugs In Class

Empty Array

Impact

Score:

7.5

Justification:

Robustly optimizes blood pressure, a critical healthspan determinant.

Evidence

Grade:

A

Score:

9

Justification:

Extensive human RCTs and meta-analyses confirm efficacy and safety.

Safety

Score:

5.5

Justification:

Common side effects, potential for serious adverse events like angioedema.

Flags

• Risk of persistent dry cough, a common side effect.
• Potential for angioedema (swelling of face, lips, tongue, throat), a rare but serious adverse event.
• May cause hyperkalemia (high potassium levels), especially with potassium supplements or diuretics.
• Risk of acute kidney injury, particularly in individuals with pre-existing renal impairment or dehydration.
• Contraindicated in pregnancy due to risk of fetal harm.
• Interacts with NSAIDs, lithium, and potassium-sparing diuretics.
• May cause symptomatic hypotension, especially with initial doses or in volume-depleted patients.

Verdict

Effective for hypertension; critical for cardiovascular and kidney health.

Model

Gemini 3 Flash

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

Lisinopril is an Angiotensin-Converting Enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action lowers blood pressure, reduces cardi...

Typical Protocol

• Commonly prescribed dosages for hypertension range from 5 mg to 40 mg once daily, titrated to achieve optimal blood pressure control, which is crucial for long-term cardiovascular and renal health.