L-Lysine is an essential amino acid required for protein synthesis and carnitine production. Its primary clinical use is for suppressing herpes simplex virus (HSV) replication. From a longevity perspective, there is emerging interest in its potential to inhibit the formation of Advanced Glycation End-products (AGEs) by competitively binding to proteins, though robust human evidence for this specific mechanism is currently lacking.
Verdict
Low-cost but unproven for direct healthspan or longevity benefits.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$5 - $20
Protocol
- Daily doses of 1000-3000 mg are common for viral suppression, a proxy for healthspan-related protocols.
Flags
- Very high doses (>10-15g/day) may cause gastrointestinal distress.
- Individuals with kidney or liver disease should consult a physician before use.
- May increase calcium absorption; use with caution if taking calcium supplements.
- Potential interaction with aminoglycoside antibiotics, increasing risk of kidney damage.