Meta Information
ID:iron-sulfate
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:36:39.412812Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron binds to bisphosphonates, forming a complex that dramatically reduces the absorption of the bone medication.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/levothyroxine
Target name:
Levothyroxine
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron binds to levothyroxine, significantly reducing the absorption and effectiveness of the thyroid hormone medication.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/levodopa
Target name:
Levodopa
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron can bind to levodopa in the gut, reducing the absorption and effectiveness of this medication.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These drugs can bind to iron in the intestine, significantly preventing its absorption into the body.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/egcg-green-tea
Target name:
Egcg
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
EGCG, a polyphenol in green tea, strongly binds to iron, significantly inhibiting its absorption from the gut.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/green-tea-extract
Target name:
Green Tea Extract
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Polyphenols in green tea extract bind tightly to iron, which significantly reduces its absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/polyphenol-rich-foods
Target name:
Polyphenol-rich Foods
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Polyphenols in foods like tea, coffee, and berries bind to iron, strongly inhibiting its absorption.
Actionable advice:
Take iron between meals.
Target id:
/intervention/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These drugs strongly reduce stomach acid, which is essential for dissolving and absorbing iron supplements effectively.
Actionable advice:
Discuss iron form with your doctor.
Target id:
/intervention/calcium-akg
Target name:
Calcium Alpha-Ketoglutarate
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Calcium competes with iron for the same absorption pathways in the gut, reducing iron uptake.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/calcium-citrate
Target name:
Calcium Citrate
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Calcium competes with iron for the same absorption pathways in the gut, reducing iron uptake.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Magnesium competes with iron for absorption in the intestine, potentially reducing the uptake of both minerals.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/zinc
Target name:
Zinc
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Zinc and iron compete for the same absorption pathways; high doses of one can reduce the other's absorption.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/famotidine
Target name:
Famotidine
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
This acid reducer lowers stomach acidity, which is necessary for the proper absorption of iron.
Actionable advice:
Discuss iron form with your doctor.
Target id:
/intervention/high-fiber-diet
Target name:
High-Fiber Diet
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Phytates found in high-fiber foods like whole grains and legumes can bind to iron, reducing absorption.
Actionable advice:
Take iron between meals.
Target id:
/intervention/phytoestrogens-soy-isoflavones
Target name:
Phytoestrogens: Soy Isoflavones
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Soy products contain phytates and proteins that can significantly inhibit the absorption of iron supplements.
Actionable advice:
Separate doses from soy by 2 hours.
Target id:
/intervention/curcumin
Target name:
Curcumin
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Curcumin is an iron chelator, meaning it can bind to iron and inhibit its absorption.
Actionable advice:
Separate doses by at least 3 hours.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Quercetin is a polyphenol that acts as an iron chelator, binding to it and reducing absorption.
Actionable advice:
Separate doses by at least 3 hours.
Target id:
/intervention/caffeine
Target name:
Caffeine
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Compounds like tannins in coffee and tea can bind to iron, reducing its absorption by over 50%.
Actionable advice:
Avoid coffee/tea 1 hour before/after iron.
Target id:
/intervention/vitamin-c
Target name:
Vitamin C
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Vitamin C significantly enhances the absorption of non-heme iron by converting it to a more usable form.
Actionable advice:
Take together for better absorption.
Target id:
/intervention/digestive-enzymes
Target name:
Digestive Enzymes
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Some enzyme formulas, particularly pancrelipase, can interfere with and reduce the absorption of iron supplements.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/alpha-lipoic-acid
Target name:
Alpha-Lipoic Acid
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Alpha-lipoic acid can bind to iron, potentially reducing the absorption of both substances in the gut.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/milk-thistle
Target name:
Milk Thistle (Silymarin)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Silymarin, the active component in milk thistle, can bind to iron and may reduce its absorption.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/myo-inositol
Target name:
Myo-inositol
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Inositols can form phytates that bind to iron, potentially reducing its absorption from the gut.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/copper
Target name:
Copper
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
High doses of copper can compete with iron for absorption, though this is rarely clinically significant.
Actionable advice:
Separate high doses by 2 hours.