Meta Information

ID:ipriflavone

Name:Ipriflavone

Schema Version:1.5

Alternate Names

• 7-isopropoxyisoflavone

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

15

High Cost:

35

Cost Type:

monthly

Description:

Over-the-counter supplement cost, not covered by insurance.

Summary

Ipriflavone is a synthetic isoflavone designed to mimic some effects of estrogen to inhibit bone resorption and preserve bone mineral density, a key factor in maintaining mobility and preventing fractures with age. However, subsequent high-quality human trials have shown it to be no more effective than placebo and have identified significant safety concerns, leading to its decline in use.

Purpose

A synthetic isoflavone intended to support bone mineral density.

Card Summary

A synthetic isoflavone once studied for osteoporosis, now largely superseded due to poor efficacy and safety concerns.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

2.1

Justification:

Limited to bone density with questionable efficacy and potential safety concerns.

Evidence

Grade:

B

Score:

3

Justification:

Human RCTs exist, but high-quality trials show no benefit over placebo.

Safety

Score:

5.5

Justification:

Risk of lymphocytopenia (lowered white blood cells), potentially impairing immune function.

Flags

• A major NIH-sponsored RCT found it no more effective than placebo for preventing bone loss.
• Associated with a significant risk of developing subclinical lymphocytopenia (low white blood cell count).
• Largely fallen out of favor in clinical practice for osteoporosis treatment.
• May interact with drugs metabolized by cytochrome P450 enzymes, like theophylline or caffeine.

Verdict

Outdated and ineffective for bone health with significant safety concerns.

Created

2026-04-26T18:30:25.815939Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Ipriflavone is a synthetic isoflavone designed to mimic some effects of estrogen to inhibit bone resorption and preserve bone mineral density, a key factor in maintaining mobility and preventing fract...

Typical Protocol

• Historical protocols for bone density involved 200 mg taken three times daily (600 mg total).