Meta Information
ID:ipriflavone
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/biomarker/complete-blood-count
Target name:
Complete Blood Count (CBC)
Severity:
major
Interaction type:
requirement
Nature:
absolute
Description:
Ipriflavone can cause a significant and potentially dangerous drop in lymphocyte counts (lymphocytopenia), a type of white blood cell, which increases the risk of serious infections.
Actionable advice:
A baseline CBC test is required before starting, with regular monitoring (e.g., every 3-6 months) during therapy.
Target id:
/condition/immunocompromised
Target name:
Immunocompromised State
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Due to the significant risk of causing low white blood cell counts (lymphocytopenia), ipriflavone is contraindicated in individuals with pre-existing conditions that compromise the immune system.
Actionable advice:
Avoid completely if you have a compromised immune system from a medical condition or medication.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9 (e.g., Warfarin, Phenytoin)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Ipriflavone is a potent inhibitor of the CYP2C9 enzyme, which can dangerously increase blood levels of medications cleared by this pathway, raising the risk of toxicity or severe side effects (e.g., bleeding with warfarin).
Actionable advice:
Avoid co-administration; if essential, it requires intensive medical monitoring and dose adjustments.
Target id:
/intervention/theophylline
Target name:
Theophylline
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Ipriflavone inhibits CYP1A2, the primary enzyme that metabolizes theophylline. This can lead to toxic accumulation of theophylline, which has a narrow therapeutic window and can cause seizures or cardiac arrhythmias.
Actionable advice:
This combination should be avoided completely.
Target id:
/condition/hepatic-impairment
Target name:
Liver Disease or Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Ipriflavone is metabolized in the liver and has been linked to cases of liver injury. Its use is contraindicated in individuals with pre-existing liver disease.
Actionable advice:
Do not use if you have any form of liver disease or impaired liver function.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
The safety of ipriflavone during pregnancy is unknown. Due to its isoflavone structure and potential hormonal effects, it poses a theoretical risk to fetal development.
Actionable advice:
Do not use if you are pregnant, planning to become pregnant, or not using effective contraception.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
It is not known whether ipriflavone or its metabolites are excreted in human milk. Due to the potential for serious adverse reactions in the nursing infant, it is contraindicated.
Actionable advice:
Do not use while breastfeeding.
Target id:
/class/cyp1a2-substrates
Target name:
Drugs Metabolized by CYP1A2
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Ipriflavone inhibits the CYP1A2 enzyme, which can increase the concentration and effects of other drugs metabolized by this pathway, such as some antidepressants and antipsychotics.
Actionable advice:
Use with caution and monitor for increased side effects of the co-administered drug.
Target id:
/class/hepatotoxic-agents
Target name:
Other Liver-Affecting Agents
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Combining ipriflavone with other drugs, supplements, or substances known to be potentially harmful to the liver (e.g., excessive alcohol, high-dose acetaminophen) may additively increase the risk of liver injury.
Actionable advice:
Minimize or avoid concurrent use of other potentially hepatotoxic substances, including alcohol.
Target id:
/class/estrogens
Target name:
Estrogens (Hormonal Therapy)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Ipriflavone may enhance the bone-protective effects of estrogen. However, this combination has not been well-studied for long-term safety and should only be used under strict medical supervision.
Actionable advice:
Only use this combination if prescribed and closely monitored by your physician.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
moderate
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking ipriflavone with food is recommended to improve its absorption and reduce the likelihood of gastrointestinal discomfort.
Actionable advice:
Always take your dose at the same time as a meal or snack.
Target id:
/intervention/calcium-citrate
Target name:
Calcium Supplements
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Ipriflavone's action to inhibit bone breakdown is most effective when the body has sufficient calcium, the primary mineral component of bone, to maintain or build new bone.
Actionable advice:
Ensure you meet daily calcium requirements through diet or supplementation as part of your bone health regimen.
Target id:
/intervention/vitamin_d3_systemic_healthspan
Target name:
Vitamin D Supplements
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Adequate vitamin D levels are crucial for the absorption of dietary calcium. Without sufficient vitamin D, the benefits of both calcium and ipriflavone on bone density are diminished.
Actionable advice:
Maintain optimal vitamin D levels through sun exposure or supplementation as recommended by your doctor.
Target id:
/condition/renal-impairment
Target name:
Kidney Disease or Impairment
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
The pharmacokinetics of ipriflavone in patients with kidney disease have not been well-studied. Caution is warranted as impaired renal function could potentially alter the drug's clearance.
Actionable advice:
Consult your physician before using if you have any degree of kidney impairment.
Target id:
/intervention/caffeine
Target name:
Caffeine
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
By inhibiting the CYP1A2 enzyme, ipriflavone can slow the metabolism of caffeine, potentially amplifying its effects such as jitteriness, increased heart rate, and difficulty sleeping.
Actionable advice:
Consider reducing your caffeine intake while taking ipriflavone to avoid potential overstimulation.