Meta Information

ID:hyaluronic-acid

Name:Hyaluronic Acid

Schema Version:1.5

Alternate Names

• HA
• Hyaluronan
• Sodium Hyaluronate

Active Compound

hyaluronic_acid

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Is Skin Health

True

Regulatory Status

• us:dietary_supplement
• eu:food_supplement

Indication

Focus:

healthspan

Description:

Aims to support joint health, skin hydration, and extracellular matrix integrity as components of healthy aging.

Typical Protocol

• Typical oral doses for healthspan support range from 100 mg to 240 mg daily, often taken with food.

Expected Cost Mean

Low Cost:

10

High Cost:

40

Cost Type:

monthly

Description:

Widely available over-the-counter supplement; not covered by insurance.

Summary

Hyaluronic acid is a key molecule in the extracellular matrix, vital for maintaining tissue hydration and lubrication, particularly in skin and joints. With age, endogenous levels decline, contributing to wrinkles and joint stiffness. Oral supplementation aims to counteract this decline, with evidence suggesting it is absorbed and distributed to tissues, potentially improving skin moisture and alleviating joint discomfort.

Purpose

Supports joint lubrication, skin hydration, and connective tissue integrity.

Card Summary

An oral supplement intended to support joint and skin health by replenishing a key component of the body's connective tissues.

Drug Class

null

Drugs In Class

Empty Array

Impact

Score:

3.8

Justification:

Targeted benefits for joint and skin health; limited evidence for broad, systemic healthspan impact.

Evidence

Grade:

B

Score:

6.5

Justification:

Human RCTs and meta-analyses support benefits for skin hydration and osteoarthritis symptoms.

Safety

Score:

2.5

Justification:

Generally recognized as safe (GRAS) with a very low incidence of adverse effects.

Flags

• Oral bioavailability is debated, though studies show absorption and tissue distribution.
• Most robust evidence is for localized benefits (skin, joints), not systemic aging.
• Rarely, may cause mild digestive upset or allergic reactions.

Verdict

A safe supplement for targeted joint and skin support, not systemic aging.

Qualifier

scope: systemic, focused on healthspan

Created

2026-05-05T22:14:00.531118Z

Ai Model

Gemini 2.5 Pro (High)