Meta Information
ID:hyaluronic-acid
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/active-cancer
Target name:
Active Cancer
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Some cancer cells have receptors (like CD44) that use hyaluronic acid for growth, proliferation, and metastasis. Oral supplementation could theoretically provide fuel for cancer progression.
Actionable advice:
Avoid oral hyaluronic acid supplements if you have an active cancer diagnosis.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of oral hyaluronic acid supplementation during pregnancy has not been established through rigorous clinical trials.
Actionable advice:
Avoid taking oral hyaluronic acid supplements during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if hyaluronic acid or its metabolites are excreted in breast milk or what effects they might have on a nursing infant; safety has not been established.
Actionable advice:
Avoid taking oral hyaluronic acid supplements while breastfeeding.
Target id:
/procedure/hyaluronic-acid-injection
Target name:
Hyaluronic Acid Injections (Fillers, Joints)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
A known allergy or hypersensitivity to hyaluronic acid products or to lidocaine (which is often mixed in) is an absolute contraindication for receiving injections.
Actionable advice:
Do not receive HA injections if you have a known allergy to the product components.
Target id:
/condition/active-skin-infection
Target name:
Active Skin Infection at Injection Site
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Injecting hyaluronic acid into an area with an active bacterial, viral (e.g., herpes simplex), or fungal infection can spread the infection and cause severe complications.
Actionable advice:
Postpone any hyaluronic acid injections until the skin infection is fully resolved.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
For injections, these drugs significantly increase the risk of bleeding, hematoma, and extensive bruising. For oral HA, there is a minor, theoretical antiplatelet effect.
Actionable advice:
Consult your doctor before taking oral HA; discontinue use 5-7 days before any planned HA injection procedure.
Target id:
/condition/history-of-cancer
Target name:
History of Cancer
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Due to the role of hyaluronic acid in cell proliferation, there is a theoretical, though unproven, risk of promoting recurrence. This warrants caution.
Actionable advice:
Consult your oncologist before using oral hyaluronic acid supplements.
Target id:
/condition/scleroderma
Target name:
Scleroderma
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Scleroderma is characterized by excessive deposition of extracellular matrix components, including hyaluronic acid. Supplementation could theoretically exacerbate this process.
Actionable advice:
Consult with your rheumatologist before using hyaluronic acid supplements.
Target id:
/class/nsaids
Target name:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
72
Hours after target:
24
Description:
When receiving HA injections, NSAIDs inhibit platelet function and increase the risk of bleeding and significant bruising at the injection site.
Actionable advice:
Discontinue NSAIDs 3-7 days before a planned HA injection and for 24 hours after, per your practitioner's advice.
Target id:
/class/herbal-anticoagulants
Target name:
Herbal Anticoagulants (Fish Oil, Ginkgo, Garlic)
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
168
Hours after target:
24
Description:
Supplements like fish oil, ginkgo biloba, garlic, and high-dose vitamin E can thin the blood, increasing the risk of bruising and bleeding from HA injections.
Actionable advice:
Discontinue supplements with blood-thinning effects 1 week prior to HA injections, as directed by your practitioner.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
2
Description:
As a large molecule (polysaccharide), oral hyaluronic acid absorption may be slightly improved when taken on an empty stomach, though evidence for this is not strong.
Actionable advice:
For potentially better absorption, take 30 minutes before a meal or wait at least 2 hours after eating.
Target id:
/intervention/collagen-peptides
Target name:
Collagen Peptides
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Hyaluronic acid helps bind water to collagen, enhancing skin hydration and joint lubrication, while collagen provides the structural framework for these tissues.
Actionable advice:
Consider taking with collagen peptides for enhanced skin and joint benefits.
Target id:
/intervention/glucosamine
Target name:
Glucosamine
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Glucosamine is a building block for cartilage and hyaluronic acid itself. Together, they provide both structural components and lubrication for joint health.
Actionable advice:
Consider taking with glucosamine for comprehensive joint support.
Target id:
/intervention/chondroitin-sulfate
Target name:
Chondroitin Sulfate
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Chondroitin provides cartilage with resistance to compression, while hyaluronic acid lubricates the joint, offering a combined and complementary benefit for joint function.
Actionable advice:
Consider taking with chondroitin sulfate for comprehensive joint support.
Target id:
/intervention/vitamin_c_systemic_healthspan
Target name:
Vitamin C
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin C is an essential cofactor for the synthesis of collagen, which works in concert with hyaluronic acid to maintain the structure and integrity of skin and connective tissues.
Actionable advice:
Ensure adequate Vitamin C intake to support the structural benefits of hyaluronic acid.
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Magnesium is a required cofactor for the enzymes (hyaluronan synthases) involved in the body's natural production of hyaluronic acid.
Actionable advice:
Ensure adequate magnesium intake to support both endogenous and supplemental hyaluronic acid function.