Meta Information
ID:green-tea-extract
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/fasting-state
Target name:
Fasted State (Empty Stomach)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Taking Green Tea Extract on an empty stomach dramatically increases the bioavailability of catechins like EGCG, which is strongly associated with a higher risk of dose-dependent liver injury.
Actionable advice:
Never take Green Tea Extract on an empty stomach; always consume it with food.
Target id:
/class/hepatotoxic-agents
Target name:
Hepatotoxic Agents
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High doses of Green Tea Extract (especially EGCG) can be hepatotoxic, and co-administration with other drugs known to cause liver stress (e.g., high-dose acetaminophen, methotrexate) can synergistically increase the risk of severe liver injury.
Actionable advice:
Avoid Green Tea Extract if you are taking any medication known to be hard on the liver.
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Individuals with pre-existing liver conditions are at a significantly higher risk of developing severe liver injury from Green Tea Extract supplementation.
Actionable advice:
Avoid Green Tea Extract completely if you have any known liver disease.
Target id:
/intervention/bortezomib
Target name:
Bortezomib (Velcade)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Polyphenols in green tea, including EGCG, can bind to and inactivate bortezomib, a proteasome inhibitor used in cancer therapy, rendering the treatment ineffective.
Actionable advice:
Absolutely avoid Green Tea Extract and green tea consumption during treatment with bortezomib.
Target id:
/intervention/nadolol
Target name:
Nadolol
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Green tea catechins inhibit the OATP1A2 transporter in the intestine, which is responsible for absorbing the beta-blocker nadolol, leading to significantly lower blood levels and reduced effectiveness.
Actionable advice:
Avoid taking Green Tea Extract if you are prescribed nadolol.
Target id:
/intervention/iron-bisglycinate
Target name:
Iron Supplements
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Polyphenols (tannins and catechins) in green tea bind to non-heme iron in the gut, forming insoluble complexes that prevent its absorption.
Actionable advice:
Separate Green Tea Extract from iron supplements by at least 2 hours.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
major
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Consuming Green Tea Extract with food slows the absorption of catechins, reducing peak plasma concentrations and mitigating the risk of liver toxicity associated with high doses.
Actionable advice:
Always take Green Tea Extract at the same time as a meal.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Green tea contains vitamin K, which can counteract the effects of warfarin. Additionally, catechins may have antiplatelet properties, potentially increasing bleeding risk when combined with other anticoagulants or antiplatelets.
Actionable advice:
Consult your doctor before using if you take blood-thinning medications, as dose adjustments may be necessary.
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Green tea catechins can inhibit the CYP3A4 metabolic enzyme, potentially increasing the blood levels and side effects of drugs metabolized by this pathway (e.g., some statins, calcium channel blockers).
Actionable advice:
Use with caution and consult a pharmacist if you take medications metabolized by CYP3A4.
Target id:
/class/cyp1a2-substrates
Target name:
CYP1A2 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Green tea catechins can inhibit the CYP1A2 enzyme, which may increase the concentration and risk of toxicity from drugs like theophylline or clozapine.
Actionable advice:
Monitor for side effects and consult your doctor if taking medications metabolized by CYP1A2.
Target id:
/intervention/folate
Target name:
Folate (Vitamin B9)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
High concentrations of green tea catechins can inhibit dihydrofolate reductase (DHFR), an enzyme essential for folate metabolism, potentially reducing the bioavailability and function of folic acid.
Actionable advice:
Ensure adequate folate intake and consider separating doses if taking high-dose Green Tea Extract.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Green Tea Extract contains caffeine and may interfere with folate metabolism, both of which are concerns during pregnancy. High doses should be avoided.
Actionable advice:
Avoid high-dose Green Tea Extract during pregnancy and consult your doctor about moderate intake.
Target id:
/condition/iron-deficiency-anemia
Target name:
Iron-Deficiency Anemia
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The catechins in Green Tea Extract strongly inhibit the absorption of non-heme iron, which can worsen iron-deficiency anemia or make it more difficult to treat.
Actionable advice:
Avoid Green Tea Extract if you have iron-deficiency anemia, or use with extreme caution far from meals.
Target id:
/dietary/iron-rich-foods
Target name:
Iron-Rich Foods
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
1
Description:
The tannins in green tea bind to non-heme iron found in plant-based foods, significantly reducing its absorption from a meal.
Actionable advice:
Avoid taking Green Tea Extract with iron-rich meals, especially if you are at risk for iron deficiency.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
8
Hours after target:
null
Description:
The caffeine in most Green Tea Extracts is a stimulant that can interfere with sleep onset and quality if taken too close to bedtime.
Actionable advice:
Avoid taking Green Tea Extract within 8 hours of your intended bedtime.
Target id:
/class/stimulants
Target name:
Stimulant Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Green Tea Extract contains caffeine and has its own mild stimulant properties, which can add to the effects of other stimulants, increasing the risk of anxiety, rapid heart rate, and high blood pressure.
Actionable advice:
Be cautious when combining with other stimulants and monitor for symptoms like jitteriness or palpitations.
Target id:
/class/ugt1a1-substrates
Target name:
UGT1A1 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
EGCG in green tea extract can inhibit the UGT1A1 enzyme, potentially increasing the toxicity of certain chemotherapy drugs like irinotecan.
Actionable advice:
Avoid Green Tea Extract if you are undergoing chemotherapy with drugs metabolized by UGT1A1.
Target id:
/biomarker/alanine-aminotransferase
Target name:
Alanine Aminotransferase (ALT)
Severity:
moderate
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
High-dose Green Tea Extract supplementation can cause idiosyncratic liver injury, leading to clinically significant elevations in liver enzymes like ALT, which can confound diagnostic testing.
Actionable advice:
Discontinue use and inform your doctor if you experience symptoms of liver distress or see elevated liver enzymes.
Target id:
/class/p-glycoprotein-substrates
Target name:
P-glycoprotein Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Green tea catechins may inhibit the P-glycoprotein efflux pump, which could slightly increase the absorption and concentration of certain drugs like digoxin.
Actionable advice:
Use with caution and monitor for side effects if taking P-glycoprotein substrate medications.
Target id:
/condition/anxiety-disorder
Target name:
Anxiety Disorders
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The caffeine content in Green Tea Extract can exacerbate symptoms of anxiety, such as nervousness, palpitations, and restlessness in susceptible individuals.
Actionable advice:
Use decaffeinated versions or start with very low doses if you have an anxiety disorder.
Target id:
/intervention/caffeine
Target name:
Caffeine
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Green Tea Extract naturally contains caffeine, and taking it with other caffeine sources will have an additive effect, potentially leading to overstimulation, anxiety, or sleep disruption.
Actionable advice:
Account for the caffeine in your extract when calculating your total daily caffeine intake.