Glutathione

Glutathione (GSH) is the body's most abundant endogenous antioxidant, crucial for neutralizing reactive oxygen species and detoxifying compounds. Its levels decline with age, contributing to increased oxidative stress, a hallmark of aging. Liposomal delivery is a technology designed to protect GSH from degradation in the gut and enhance its absorption, theoretically raising systemic levels more effectively than standard oral GSH.

Verdict

A safe but unproven strategy for boosting antioxidant defense via supplementation.

Protocol

• Typical doses range from 250 mg to 1000 mg per day, often taken on an empty stomach for better absorption.

Flags

• Quality and bioavailability can vary significantly between different liposomal supplement brands.
• May cause mild gastrointestinal upset, such as bloating or cramps, in some individuals.
• Precursors like NAC and Glycine may be more effective at raising intracellular glutathione levels.
• Individuals with sulfite sensitivities or asthma should use with caution.