Meta Information

ID:glutathione

Name:Glutathione

Schema Version:1.5

Alternate Names

• L-Glutathione
• GSH
• Liposomal GSH

Active Compound

glutathione

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement
• eu:food_supplement

Indication

Focus:

healthspan

Description:

Aims to increase systemic levels of the body's master antioxidant, glutathione, to combat oxidative stress and support cellular function.

Typical Protocol

• Typical doses range from 250 mg to 1000 mg per day, often taken on an empty stomach for better absorption.

Expected Cost Mean

Low Cost:

40

High Cost:

90

Cost Type:

monthly

Description:

Cost for a 30-day supply of a reputable liposomal glutathione supplement; not covered by insurance.

Summary

Glutathione (GSH) is the body's most abundant endogenous antioxidant, crucial for neutralizing reactive oxygen species and detoxifying compounds. Its levels decline with age, contributing to increased oxidative stress, a hallmark of aging. Liposomal delivery is a technology designed to protect GSH from degradation in the gut and enhance its absorption, theoretically raising systemic levels more effectively than standard oral GSH.

Purpose

Boosts the body's master antioxidant to reduce cellular damage.

Card Summary

A master antioxidant supplement designed for enhanced absorption to combat age-related oxidative stress.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Theoretically potent, but human data showing healthspan extension from supplementation is limited.

Evidence

Grade:

C

Score:

3

Justification:

Small human trials confirm bioavailability, but lack long-term healthspan outcome data.

Safety

Score:

2.5

Justification:

Generally recognized as safe (GRAS) with a low incidence of mild side effects.

Flags

• Quality and bioavailability can vary significantly between different liposomal supplement brands.
• May cause mild gastrointestinal upset, such as bloating or cramps, in some individuals.
• Precursors like NAC and Glycine may be more effective at raising intracellular glutathione levels.
• Individuals with sulfite sensitivities or asthma should use with caution.

Verdict

A safe but unproven strategy for boosting antioxidant defense via supplementation.

Qualifier

route: liposomal, scope: systemic, focused on healthspan

Created

2026-05-06T01:31:34.441678Z

Ai Model

Gemini 2.5 Pro (High)