Glucosamine is an amino sugar that serves as a building block for cartilage and other connective tissues. Its relevance to healthspan is supported by large observational studies linking its regular use to a significant reduction in all-cause mortality. The proposed mechanism involves mimicking some metabolic effects of a low-carbohydrate diet, potentially by modulating glucose metabolism and reducing systemic inflammation.
Verdict
A safe, low-cost supplement with promising observational data for longevity.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $30
Protocol
- Daily supplementation of 1500 mg of glucosamine sulfate is a common protocol.
Flags
- May interact with warfarin and other blood thinners, increasing bleeding risk.
- Often derived from shellfish; may cause reactions in those with shellfish allergies.
- May affect blood sugar levels; caution is advised for individuals with diabetes.