Meta Information

ID:glucosamine

Name:Glucosamine

Schema Version:1.5

Alternate Names

• Glucosamine Sulfate
• Glucosamine Hydrochloride
• N-Acetyl Glucosamine

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

10

High Cost:

30

Cost Type:

monthly

Description:

Widely available over-the-counter supplement, not covered by insurance.

Summary

Glucosamine is an amino sugar that serves as a building block for cartilage and other connective tissues. Its relevance to healthspan is supported by large observational studies linking its regular use to a significant reduction in all-cause mortality. The proposed mechanism involves mimicking some metabolic effects of a low-carbohydrate diet, potentially by modulating glucose metabolism and reducing systemic inflammation.

Purpose

Supports joint health and may mimic low-carb metabolic benefits.

Card Summary

An amino sugar for joint health with emerging observational evidence for longevity benefits.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Observational data suggests mortality reduction, but lacks longevity-focused RCTs.

Evidence

Grade:

B

Score:

6.5

Justification:

Strong observational data links use to lower mortality; lacks specific longevity RCTs.

Safety

Score:

3

Justification:

Generally recognized as safe (GRAS) with a long history of use.

Flags

• May interact with warfarin and other blood thinners, increasing bleeding risk.
• Often derived from shellfish; may cause reactions in those with shellfish allergies.
• May affect blood sugar levels; caution is advised for individuals with diabetes.

Verdict

A safe, low-cost supplement with promising observational data for longevity.

Created

2026-04-26T18:15:13.686796Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Glucosamine is an amino sugar that serves as a building block for cartilage and other connective tissues. Its relevance to healthspan is supported by large observational studies linking its regular us...

Typical Protocol

• Daily supplementation of 1500 mg of glucosamine sulfate is a common protocol.