EGCG is the most abundant catechin in green tea, acting as a potent antioxidant and anti-inflammatory agent. It is studied for its ability to activate pathways like AMPK, which are involved in cellular energy regulation, and to potentially induce apoptosis in senescent or cancerous cells, thereby supporting metabolic health and cellular cleanup processes relevant to aging.
Verdict
A promising antioxidant, best consumed via green tea for optimal safety.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $30
Protocol
- Typical supplemental doses range from 200 mg to 800 mg of EGCG per day.
- Consuming 3-5 cups of high-quality green tea daily provides a natural source of EGCG.
- Often taken with food to minimize potential gastrointestinal upset and improve tolerability.
Flags
- High-dose supplements (>800 mg/day) are linked to a risk of liver damage.
- May interfere with the absorption of iron and folic acid.
- Can interact with certain medications, including blood thinners and some chemotherapy drugs.
- Taking EGCG on an empty stomach may increase the risk of nausea.