Meta Information
ID:egcg-green-tea
Name:Egcg
Schema Version:1.5
Alternate Names
- Epigallocatechin gallate
- Green Tea Extract
Active Compound
Epigallocatechin gallate
Intervention Type
therapeutic_agent
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
- eu:food_supplement
Indication
Focus:
healthspan
Description:
Targets cellular senescence, oxidative stress, and inflammation, with potential benefits for metabolic and cardiovascular health.
Typical Protocol
- Typical supplemental doses range from 200 mg to 800 mg of EGCG per day.
- Consuming 3-5 cups of high-quality green tea daily provides a natural source of EGCG.
- Often taken with food to minimize potential gastrointestinal upset and improve tolerability.
Expected Cost Mean
Low Cost:
10
High Cost:
30
Cost Type:
monthly
Description:
Cost for daily EGCG supplements, not typically covered by insurance.
Summary
EGCG is the most abundant catechin in green tea, acting as a potent antioxidant and anti-inflammatory agent. It is studied for its ability to activate pathways like AMPK, which are involved in cellular energy regulation, and to potentially induce apoptosis in senescent or cancerous cells, thereby supporting metabolic health and cellular cleanup processes relevant to aging.
Purpose
A potent green tea antioxidant targeting inflammation and cellular stress.
Card Summary
A potent antioxidant from green tea, EGCG is studied for its role in reducing inflammation, supporting metabolic health, and clearing senescent cells, though human healthspan evidence is still developing.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
4.5
Justification:
Moderate effects on multiple aging pathways like inflammation and oxidative stress.
Evidence
Grade:
B
Score:
6.5
Justification:
Strong observational data and human biomarker trials, but lacks large healthspan RCTs.
Safety
Score:
3.8
Justification:
Generally safe, but high-dose supplements carry a known risk of liver toxicity.
Flags
- High-dose supplements (>800 mg/day) are linked to a risk of liver damage.
- May interfere with the absorption of iron and folic acid.
- Can interact with certain medications, including blood thinners and some chemotherapy drugs.
- Taking EGCG on an empty stomach may increase the risk of nausea.
Verdict
A promising antioxidant, best consumed via green tea for optimal safety.
Created
2026-05-05T21:59:19.855189Z
Ai Model
Gemini 2.5 Pro (High)