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Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNA-11

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An experimental peptide studied for neurogenesis and cognitive repair.

Dihexa is a synthetic peptide designed to be a potent activator of Hepatocyte Growth Factor (HGF) and its receptor, c-Met. In animal models, this activation promotes the formation of new synapses (synaptogenesis) and has shown potential in repairing neurological damage. Its relevance to healthspan is purely theoretical, focusing on the potential to counteract age-related cognitive decline and neurodegeneration, but it completely lacks human clinical data.

Verdict

A highly speculative research chemical with no human data; avoid.

HEALTHSPAN IMPACT

Experimental

RISK LEVEL

Very High

EVIDENCE GRADE

C

MONTHLY COST

$30 - $80

Protocol

  • As a research chemical, no established human protocol exists; anecdotal use involves topical or injected low-milligram doses.

Flags

  • Completely lacks human safety, dosing, or efficacy data.
  • Sourced from unregulated 'research chemical' suppliers, posing a high risk of contamination or incorrect dosage.
  • Long-term effects of potent HGF/c-Met activation are unknown and pose a theoretical cancer risk.
  • Not approved for human consumption by any regulatory agency.