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Daily Low-Dose Tadalafil

Cialis (daily), PDE5 inhibitor

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Meta Information

ID:daily-low-dose-tadalafil
Name:Daily Low-Dose Tadalafil
Schema Version:1.5

Alternate Names

  • Cialis (daily)
  • PDE5 inhibitor

Active Compound

tadalafil

Intervention Type

therapeutic_agent

Delivery

Route:
oral
Scope:
  • systemic

Regulatory Status

  • us:rx_drug
  • eu:rx_drug

Indication

Focus:
healthspan
Description:
Targets improved endothelial function, blood flow, and nitric oxide signaling for broad cardiovascular and metabolic benefits.

Typical Protocol

  • Daily doses typically range from 2.5mg to 5mg for healthspan applications.
  • Taken orally at approximately the same time each day, with or without food.

Expected Cost Mean

Low Cost:
10
High Cost:
60
Cost Type:
monthly
Description:
Generic versions are widely available; typically not covered by insurance for healthspan purposes.

Summary

Tadalafil is a long-acting phosphodiesterase 5 (PDE5) inhibitor. By blocking the PDE5 enzyme, it increases levels of cyclic guanosine monophosphate (cGMP), which relaxes smooth muscle and causes vasodilation (widening of blood vessels). This mechanism improves systemic blood flow and endothelial function, which are foundational to cardiovascular health and may mitigate age-related declines in tissue perfusion and oxygenation.

Purpose

Enhances systemic blood flow and endothelial function via PDE5 inhibition.

Card Summary

A daily low-dose PDE5 inhibitor that improves systemic blood flow and endothelial function, with potential benefits for cardiovascular and metabolic health.

Drug Class

pde5_inhibitors

Drugs In Class

Empty Array

Impact

Score:
5.5
Justification:
Improves endothelial function and blood flow, key markers of cardiovascular aging.

Evidence

Grade:
B
Score:
6.5
Justification:
Robust human data for primary indications; emerging human data for healthspan-related endpoints.

Safety

Score:
4.5
Justification:
Well-established safety profile but requires prescription due to significant drug interactions (nitrates).

Flags

  • Contraindicated with nitrate medications (e.g., nitroglycerin) due to risk of severe hypotension.
  • Use with caution alongside alpha-blockers or other antihypertensive drugs.
  • Common side effects include headache, flushing, indigestion, back pain, and nasal congestion.
  • Rare but serious side effects include sudden vision or hearing loss.
  • Priapism (prolonged erection) is a rare medical emergency requiring immediate attention.

Verdict

Promising for cardiovascular health, but requires medical supervision due to drug interactions.

Created

2026-05-06T21:59:53.285744Z

Ai Model

Gemini 2.5 Pro (High)