Meta Information
ID:daily-low-dose-tadalafil
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:49:08.825488Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/intervention/pde5-inhibitors
Target name:
PDE5 Inhibitors
Severity:
major
Interaction type:
contraindicated
Nature:
absolute
Description:
Using two drugs from the same class is redundant and dangerously increases risk of side effects.
Actionable advice:
Never combine with other PDE5 inhibitors.
Target id:
/dietary/grapefruit-pomelo
Target name:
Grapefruit, Pomelo, and Seville Oranges
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Grapefruit blocks the enzyme that breaks down tadalafil, increasing drug levels and side effects.
Actionable advice:
Avoid grapefruit products entirely.
Target id:
/intervention/saint-johns-wort
Target name:
Saint John's Wort
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
St. John's Wort speeds up tadalafil's breakdown, significantly reducing its effectiveness.
Actionable advice:
Avoid taking together.
Target id:
/intervention/ace-inhibitors
Target name:
ACE Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Taking with blood pressure medications like ACE inhibitors can cause an excessive drop in blood pressure.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/amlodipine
Target name:
Amlodipine
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Taking with blood pressure medications like amlodipine can cause an excessive drop in blood pressure.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/angiotensin-receptor-blockers
Target name:
Angiotensin Receptor Blockers
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Taking with blood pressure medications like ARBs can cause an excessive drop in blood pressure.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/metoprolol
Target name:
Metoprolol
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Taking with blood pressure medications like metoprolol can cause an excessive drop in blood pressure.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/mtor-inhibitors
Target name:
mTOR Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Tadalafil can affect the metabolism of mTOR inhibitors, potentially altering their levels and toxicity risk.
Actionable advice:
Requires specialist dose management.
Target id:
/intervention/nebivolol
Target name:
Nebivolol
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Taking with blood pressure medications like nebivolol can cause an excessive drop in blood pressure.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/propranolol
Target name:
Propranolol
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Taking with blood pressure medications like propranolol can cause an excessive drop in blood pressure.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/beetroot-juice
Target name:
Beetroot Juice
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Beetroot contains nitrates that, combined with tadalafil, can cause a significant drop in blood pressure.
Actionable advice:
Monitor blood pressure carefully.
Target id:
/intervention/sglt2-inhibitors
Target name:
SGLT2 Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
These diabetes drugs increase urination and can lower blood pressure, adding to tadalafil's effects.
Actionable advice:
Monitor blood pressure and hydration.
Target id:
/intervention/glp-1-receptor-agonists
Target name:
GLP-1 Receptor Agonists
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
These diabetes drugs can lower blood pressure, adding to tadalafil's effect and increasing dizziness risk.
Actionable advice:
Monitor blood pressure.
Target id:
/dietary/alcohol-acute
Target name:
Acute Alcohol Consumption
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Alcohol can increase the blood pressure-lowering effects of tadalafil, causing dizziness or fainting.
Actionable advice:
Limit alcohol intake.
Target id:
/intervention/berberine
Target name:
Berberine
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Berberine may inhibit tadalafil's breakdown, potentially increasing its levels and side effects like low blood pressure.
Actionable advice:
Monitor for increased side effects.
Target id:
/intervention/cannabis
Target name:
Cannabis
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Cannabis can also lower blood pressure, potentially leading to dizziness when combined with tadalafil.
Actionable advice:
Use with caution.
Target id:
/intervention/milk-thistle
Target name:
Milk Thistle (Silymarin)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Milk thistle may inhibit tadalafil's breakdown, potentially increasing its levels and side effects.
Actionable advice:
Monitor for increased side effects.
Target id:
/intervention/statins
Target name:
Statins
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Some statins and tadalafil use the same enzyme, potentially increasing drug levels and side effects.
Actionable advice:
Monitor for muscle pain or other side effects.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Quercetin may inhibit tadalafil's breakdown, potentially increasing its levels and side effects.
Actionable advice:
Monitor for increased side effects.
Target id:
/intervention/cocoa-flavanols
Target name:
Cocoa Flavanols
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Cocoa flavanols can lower blood pressure, which may add to the effects of tadalafil.
Actionable advice:
Monitor blood pressure if using high doses.
Target id:
/intervention/curcumin
Target name:
Curcumin
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Curcumin may mildly inhibit tadalafil's breakdown, slightly increasing its levels and potential side effects.
Actionable advice:
Monitor if side effects occur.
Target id:
/intervention/niacin
Target name:
Niacin (Vitamin B3)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Both can cause flushing (skin redness and warmth); taking them together may worsen this effect.
Actionable advice:
Be aware of potential for increased flushing.
Target id:
/intervention/theophylline
Target name:
Theophylline
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Tadalafil may slightly increase the breakdown of theophylline, potentially reducing its effectiveness.
Actionable advice:
Generally no action needed.