D-Mannose is a simple sugar that prevents E. coli from adhering to urinary tract walls, facilitating their removal and preventing infections. Its primary healthspan relevance is indirect, by reducing the chronic inflammation and antibiotic use associated with recurrent UTIs, thereby supporting microbiome health and mitigating a driver of inflammaging.
Verdict
A safe, evidence-based tool for preventing recurrent UTIs and associated inflammation.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$10 - $25
Protocol
- A daily dose of 2 grams is often used for preventing recurrent urinary tract infections.
Flags
- Not a substitute for antibiotics for an active or complicated urinary tract infection.
- High doses may cause bloating, diarrhea, or other gastrointestinal discomfort.
- Use with caution in individuals with diabetes due to its sugar structure, though glycemic impact is low.