Meta Information

ID:d-mannose

Name:D-Mannose

Schema Version:1.5

Title

D-Mannose

Alternate Names

• Mannose

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

10

High Cost:

25

Cost Type:

monthly

Description:

Widely available as an affordable bulk powder or in capsule form.

Summary

D-Mannose is a simple sugar that prevents E. coli from adhering to urinary tract walls, facilitating their removal and preventing infections. Its primary healthspan relevance is indirect, by reducing the chronic inflammation and antibiotic use associated with recurrent UTIs, thereby supporting microbiome health and mitigating a driver of inflammaging.

Purpose

A simple sugar that prevents UTIs, reducing inflammation and antibiotic use.

Card Summary

A simple sugar that prevents UTIs by blocking bacterial adhesion, indirectly reducing chronic inflammation.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.2

Justification:

Highly effective for a specific issue (UTIs), indirectly reducing inflammation and antibiotic use.

Evidence

Grade:

A

Score:

8.5

Justification:

Multiple human RCTs and meta-analyses confirm efficacy for UTI prevention.

Safety

Score:

2.5

Justification:

Generally recognized as safe (GRAS) with mild, dose-dependent gastrointestinal side effects.

Flags

• Not a substitute for antibiotics for an active or complicated urinary tract infection.
• High doses may cause bloating, diarrhea, or other gastrointestinal discomfort.
• Use with caution in individuals with diabetes due to its sugar structure, though glycemic impact is low.

Verdict

A safe, evidence-based tool for preventing recurrent UTIs and associated inflammation.

Created

2026-04-23T23:24:40.785872Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

multiple

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

D-Mannose is a simple sugar that prevents E. coli from adhering to urinary tract walls, facilitating their removal and preventing infections. Its primary healthspan relevance is indirect, by reducing ...

Typical Protocol

• A daily dose of 2 grams is often used for preventing recurrent urinary tract infections.