Curcumin is a polyphenol from turmeric with potent anti-inflammatory and antioxidant properties, but it has very poor bioavailability. Piperine, an alkaloid from black pepper, inhibits key metabolic enzymes, increasing curcumin's absorption and blood concentration by up to 2000%. This enhancement allows curcumin to exert systemic effects against inflammaging and oxidative stress throughout the body.
Verdict
A well-evidenced, safe anti-inflammatory, but check for crucial drug interactions.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$15 - $40
Protocol
- Daily doses typically range from 500-1000 mg of curcuminoids.
- Piperine is included at 5-20 mg per dose to enhance absorption.
- Often taken with a meal containing fat to further improve bioavailability.
Flags
- Piperine can slow the metabolism of many pharmaceutical drugs, increasing their effects and risks.
- High doses may cause gastrointestinal distress, such as nausea or diarrhea.
- May have anti-platelet effects; use with caution if taking blood thinners like warfarin.
- Discontinue use at least two weeks before scheduled surgery due to potential effects on blood clotting.