Meta Information
ID:curcumin-and-piperine
Name:Curcumin and Piperine
Schema Version:1.5
Alternate Names
- Turmeric and Black Pepper Extract
- Bioavailable Curcumin
Active Compound
Curcumin
Intervention Type
synergistic_therapy
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
- eu:food_supplement
Indication
Focus:
healthspan
Description:
Targeting systemic, low-grade chronic inflammation (inflammaging) and oxidative stress, which are key drivers of aging.
Typical Protocol
- Daily doses typically range from 500-1000 mg of curcuminoids.
- Piperine is included at 5-20 mg per dose to enhance absorption.
- Often taken with a meal containing fat to further improve bioavailability.
Expected Cost Mean
Low Cost:
15
High Cost:
40
Cost Type:
monthly
Description:
Monthly supply of a quality-tested curcumin/piperine combination supplement; not covered by insurance.
Summary
Curcumin is a polyphenol from turmeric with potent anti-inflammatory and antioxidant properties, but it has very poor bioavailability. Piperine, an alkaloid from black pepper, inhibits key metabolic enzymes, increasing curcumin's absorption and blood concentration by up to 2000%. This enhancement allows curcumin to exert systemic effects against inflammaging and oxidative stress throughout the body.
Purpose
Potent anti-inflammatory and antioxidant with enhanced bioavailability for systemic effects.
Card Summary
A potent anti-inflammatory compound from turmeric, its bioavailability is increased 2000% by piperine, targeting systemic inflammation.
Drug Class
null
Drugs In Class
Empty Array
Impact
Score:
4.5
Justification:
Effectively targets inflammation and oxidative stress, but direct human healthspan extension data is limited.
Evidence
Grade:
A
Score:
8.5
Justification:
Numerous human RCTs and meta-analyses confirm potent anti-inflammatory and antioxidant effects.
Safety
Score:
2.5
Justification:
Generally Recognized As Safe (GRAS) with a long history of culinary and supplemental use.
Flags
- Piperine can slow the metabolism of many pharmaceutical drugs, increasing their effects and risks.
- High doses may cause gastrointestinal distress, such as nausea or diarrhea.
- May have anti-platelet effects; use with caution if taking blood thinners like warfarin.
- Discontinue use at least two weeks before scheduled surgery due to potential effects on blood clotting.
Verdict
A well-evidenced, safe anti-inflammatory, but check for crucial drug interactions.
Qualifier
route: oral, scope: systemic, focused on healthspan. Highlight the 2000 percent bioavailability increase.
Created
2026-04-30T01:41:42.475875Z
Ai Model
Gemini 2.5 Pro (High)