Meta Information

ID:chromium-polynicotinate

Name:Chromium Polynicotinate

Schema Version:1.5

Alternate Names

• Chromium Niacinate
• Chromium Nicotinate

Active Compound

Chromium

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement
• eu:food_supplement

Indication

Focus:

healthspan

Description:

Aims to improve insulin sensitivity and glucose metabolism, which are foundational to metabolic health and healthy aging.

Typical Protocol

• Typical doses range from 200 to 1000 micrograms (mcg) per day, often taken with meals to improve absorption.

Expected Cost Mean

Low Cost:

10

High Cost:

25

Cost Type:

monthly

Description:

Widely available as an inexpensive over-the-counter dietary supplement; not covered by insurance.

Summary

Chromium is an essential trace mineral that may enhance the action of insulin, a hormone critical for metabolizing and storing carbohydrates, fat, and protein. By potentially improving insulin sensitivity, chromium polynicotinate is proposed to support stable blood glucose levels, which is a key factor in preventing age-related metabolic decline.

Purpose

A mineral supplement intended to improve insulin sensitivity and glucose control.

Card Summary

A form of the essential mineral chromium, studied for its potential to improve insulin sensitivity and support healthy blood sugar levels.

Drug Class

chromium

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Benefits are modest and primarily seen in individuals with existing insulin resistance or deficiency.

Evidence

Grade:

B

Score:

5

Justification:

Many human RCTs exist, but meta-analyses show inconsistent and often null results.

Safety

Score:

2.5

Justification:

Generally recognized as safe at typical doses, with rare reports of adverse effects.

Flags

• High doses (>1000 mcg/day) have been linked to rare cases of kidney damage.
• May interact with diabetes medications (e.g., insulin, metformin), requiring dose adjustments.
• Individuals with pre-existing kidney or liver disease should consult a physician before use.

Verdict

Potentially useful for insulin resistance, but limited evidence for general healthspan.

Created

2026-05-06T18:41:17.599857Z

Ai Model

Gemini 2.5 Pro (High)