Cannabis contains compounds like THC and CBD that interact with the body's endocannabinoid system (ECS), a master regulator of homeostasis. By modulating the ECS, cannabis may influence inflammation, neurotransmission, and metabolic function. Its relevance to longevity is primarily indirect, through the management of symptoms like chronic pain, poor sleep, and anxiety, which can otherwise negatively impact healthspan.
Verdict
A tool for symptom management, not a core healthspan intervention.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
C
MONTHLY COST
$30 - $100
Protocol
- Low-dose CBD (5-25mg) daily for inflammation and anxiety management.
- Microdosing THC (<2.5mg) for sleep or pain, avoiding psychoactive effects.
- Topical CBD application for localized joint pain and inflammation.
Flags
- Psychoactive effects of THC can impair cognition, coordination, and judgment.
- Inhalation methods (smoking/vaping) pose significant risks to lung health.
- Potential for psychological dependence and Cannabis Use Disorder.
- Interacts with sedatives, blood thinners (like warfarin), and some antidepressants.
- Legality and product quality vary significantly by jurisdiction.
- Long-term cognitive effects, especially with adolescent use, are a major concern.