Meta Information
ID:cannabis
Name:Cannabis
Schema Version:1.5
Title
Cannabis
Alternate Names
- Marijuana
- THC
- CBD
- Cannabinoids
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
30
High Cost:
100
Cost Type:
monthly
Description:
Cost for daily low-dose CBD oil or occasional low-dose THC edibles.
Summary
Cannabis contains compounds like THC and CBD that interact with the body's endocannabinoid system (ECS), a master regulator of homeostasis. By modulating the ECS, cannabis may influence inflammation, neurotransmission, and metabolic function. Its relevance to longevity is primarily indirect, through the management of symptoms like chronic pain, poor sleep, and anxiety, which can otherwise negatively impact healthspan.
Purpose
Modulates the endocannabinoid system to manage inflammation and stress.
Card Summary
Modulates the body's endocannabinoid system (ECS), a master regulator of homeostasis, potentially impacting inflammation, sleep, pain, and stress pathways relevant to aging.
Drug Class
cannabinoids
Drugs In Class
- tetrahydrocannabinol-thc
- cannabidiol-cbd
- cannabigerol-cbg
- cannabinol-cbn
Impact
Score:
3.5
Justification:
Indirect benefits via symptom management (sleep, pain) but no direct pro-longevity evidence.
Evidence
Grade:
C
Score:
3
Justification:
Primarily preclinical or observational data for longevity; human trials focus on disease treatment.
Safety
Score:
5.5
Justification:
Psychoactive effects, dependency potential, and cognitive risks associated with THC are significant.
Flags
- Psychoactive effects of THC can impair cognition, coordination, and judgment.
- Inhalation methods (smoking/vaping) pose significant risks to lung health.
- Potential for psychological dependence and Cannabis Use Disorder.
- Interacts with sedatives, blood thinners (like warfarin), and some antidepressants.
- Legality and product quality vary significantly by jurisdiction.
- Long-term cognitive effects, especially with adolescent use, are a major concern.
Verdict
A tool for symptom management, not a core healthspan intervention.
Created
2026-04-23T22:58:19.436555Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
multiple
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Cannabis contains compounds like THC and CBD that interact with the body's endocannabinoid system (ECS), a master regulator of homeostasis. By modulating the ECS, cannabis may influence inflammation, ...
Typical Protocol
- Low-dose CBD (5-25mg) daily for inflammation and anxiety management.
- Microdosing THC (<2.5mg) for sleep or pain, avoiding psychoactive effects.
- Topical CBD application for localized joint pain and inflammation.