Bromelain is a complex of protein-digesting enzymes derived from the pineapple plant. Its primary mechanism involves modulating inflammatory pathways, such as inhibiting COX-2 expression and reducing pro-inflammatory cytokines. From a healthspan perspective, this systemic anti-inflammatory activity may help counteract 'inflammaging,' the chronic, low-grade inflammation that is a key driver of many age-related diseases.
Verdict
A useful tool for targeted inflammation, not a core longevity intervention.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $30
Protocol
- Take 500-1000 mg daily on an empty stomach to maximize systemic absorption.
Flags
- May increase the effects of anticoagulant and antiplatelet drugs (e.g., Warfarin, Aspirin).
- Can enhance the absorption and effects of certain antibiotics like amoxicillin and tetracycline.
- Individuals with pineapple, latex, or certain pollen allergies may have allergic reactions.