Meta Information

ID:bromelain

Name:Bromelain

Schema Version:1.5

Title

Bromelain

Alternate Names

• Pineapple Extract
• Ananase

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

10

High Cost:

30

Cost Type:

monthly

Description:

Cost for a standard 500mg daily dose from reputable supplement brands.

Summary

Bromelain is a complex of protein-digesting enzymes derived from the pineapple plant. Its primary mechanism involves modulating inflammatory pathways, such as inhibiting COX-2 expression and reducing pro-inflammatory cytokines. From a healthspan perspective, this systemic anti-inflammatory activity may help counteract 'inflammaging,' the chronic, low-grade inflammation that is a key driver of many age-related diseases.

Purpose

A pineapple-derived enzyme complex that reduces systemic inflammation.

Card Summary

A pineapple-derived enzyme complex that reduces systemic inflammation, potentially mitigating age-related chronic inflammation (inflammaging).

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Provides targeted anti-inflammatory benefits, but lacks direct evidence for systemic healthspan extension.

Evidence

Grade:

B

Score:

5.5

Justification:

Human trials exist for specific inflammatory conditions, but not for general longevity outcomes.

Safety

Score:

3

Justification:

Generally safe with low side effect profile, but can increase bleeding risk.

Flags

• May increase the effects of anticoagulant and antiplatelet drugs (e.g., Warfarin, Aspirin).
• Can enhance the absorption and effects of certain antibiotics like amoxicillin and tetracycline.
• Individuals with pineapple, latex, or certain pollen allergies may have allergic reactions.

Verdict

A useful tool for targeted inflammation, not a core longevity intervention.

Created

2026-04-23T22:57:36.558838Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Bromelain is a complex of protein-digesting enzymes derived from the pineapple plant. Its primary mechanism involves modulating inflammatory pathways, such as inhibiting COX-2 expression and reducing ...

Typical Protocol

• Take 500-1000 mg daily on an empty stomach to maximize systemic absorption.