Blood donation, or therapeutic phlebotomy, systematically reduces the body's iron stores. Excess iron acts as a pro-oxidant, catalyzing the formation of free radicals that damage cells, lipids, and DNA, which is a key driver of aging. By lowering ferritin levels, this intervention may reduce oxidative stress, improve insulin sensitivity, and decrease the risk of cardiovascular and metabolic diseases.
Verdict
A powerful, low-cost intervention to manage a key pro-aging mineral.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$0 - $200
Protocol
- Donate one unit (approx. 450-500 mL) every 3 to 6 months, guided by ferritin levels.
- Men may donate up to 4 times per year; pre-menopausal women typically require less frequent donation.
- Target ferritin levels between 30-80 ng/mL for healthspan optimization.
Flags
- Risk of inducing iron-deficiency anemia if performed too frequently or without monitoring ferritin levels.
- Not suitable for individuals with anemia or certain blood disorders.
- Temporary side effects include dizziness, fatigue, or bruising at the needle site.
- Ensure adequate hydration and nutrition post-donation.