Meta Information

ID:blood-donation

Name:Blood Donation (Therapeutic Phlebotomy)

Schema Version:1.5

Alternate Names

• Phlebotomy
• Venesection

Intervention Type

procedure

Expected Cost Mean

Low Cost:

0

High Cost:

200

Cost Type:

procedure

Description:

Voluntary donation is free; prescribed therapeutic phlebotomy may have a cost.

Summary

Blood donation, or therapeutic phlebotomy, systematically reduces the body's iron stores. Excess iron acts as a pro-oxidant, catalyzing the formation of free radicals that damage cells, lipids, and DNA, which is a key driver of aging. By lowering ferritin levels, this intervention may reduce oxidative stress, improve insulin sensitivity, and decrease the risk of cardiovascular and metabolic diseases.

Purpose

Reduces excess body iron to lower oxidative stress and disease risk.

Card Summary

Reduces excess iron stores to mitigate oxidative stress, a key driver of aging.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

7.2

Justification:

Systematically reduces a key pro-oxidant (iron), impacting multiple age-related disease pathways.

Evidence

Grade:

B

Score:

6.5

Justification:

Strong observational data and mechanistic rationale; lacks large-scale longevity RCTs.

Safety

Score:

3.5

Justification:

Generally very safe in a clinical setting; risk of temporary side effects or anemia.

Flags

• Risk of inducing iron-deficiency anemia if performed too frequently or without monitoring ferritin levels.
• Not suitable for individuals with anemia or certain blood disorders.
• Temporary side effects include dizziness, fatigue, or bruising at the needle site.
• Ensure adequate hydration and nutrition post-donation.

Verdict

A powerful, low-cost intervention to manage a key pro-aging mineral.

Model

Gemini 3.1 Pro (High)

Delivery

Route:

none

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Blood donation, or therapeutic phlebotomy, systematically reduces the body's iron stores. Excess iron acts as a pro-oxidant, catalyzing the formation of free radicals that damage cells, lipids, and DN...

Typical Protocol

• Donate one unit (approx. 450-500 mL) every 3 to 6 months, guided by ferritin levels.
• Men may donate up to 4 times per year; pre-menopausal women typically require less frequent donation.
• Target ferritin levels between 30-80 ng/mL for healthspan optimization.