Betaine (TMG) is a methyl donor that plays a critical role in the methionine cycle by helping to convert homocysteine back into methionine. This action helps lower potentially harmful homocysteine levels and supports the body's overall methylation capacity, a fundamental process linked to epigenetic regulation and cellular health.
Verdict
A safe, inexpensive way to support methylation and lower homocysteine.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $25
Protocol
- Daily dosages typically range from 500mg to 3,000mg, often divided into two doses.
Flags
- May increase LDL cholesterol levels in some individuals at higher doses.
- Can cause mild gastrointestinal distress, such as nausea or diarrhea.
- May interact with methotrexate; consult a physician if taking this medication.