Meta Information
ID:betaine
Name:Betaine (TMG)
Schema Version:1.5
Title
Betaine (TMG)
Alternate Names
- Trimethylglycine
- TMG
- Glycine Betaine
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
10
High Cost:
25
Cost Type:
monthly
Description:
Widely available and inexpensive as a bulk powder or capsule.
Summary
Betaine (TMG) is a methyl donor that plays a critical role in the methionine cycle by helping to convert homocysteine back into methionine. This action helps lower potentially harmful homocysteine levels and supports the body's overall methylation capacity, a fundamental process linked to epigenetic regulation and cellular health.
Purpose
Supports methylation, lowers homocysteine, and protects liver function.
Card Summary
A methyl donor that lowers homocysteine and supports crucial cellular methylation processes.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
5.5
Justification:
Supports a fundamental aging pathway (methylation) and reduces a key risk marker (homocysteine).
Evidence
Grade:
B
Score:
6.5
Justification:
Strong human data for lowering homocysteine, but indirect evidence for extending healthspan.
Safety
Score:
3
Justification:
Generally Recognized As Safe (GRAS) with a long history of use; minimal side effects.
Flags
- May increase LDL cholesterol levels in some individuals at higher doses.
- Can cause mild gastrointestinal distress, such as nausea or diarrhea.
- May interact with methotrexate; consult a physician if taking this medication.
Verdict
A safe, inexpensive way to support methylation and lower homocysteine.
Created
2026-04-23T22:55:33.163401Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Betaine (TMG) is a methyl donor that plays a critical role in the methionine cycle by helping to convert homocysteine back into methionine. This action helps lower potentially harmful homocysteine lev...
Typical Protocol
- Daily dosages typically range from 500mg to 3,000mg, often divided into two doses.