Benfotiamine

Benfotiamine is a fat-soluble, highly bioavailable derivative of thiamine (Vitamin B1). It works by activating the enzyme transketolase, which shunts harmful glucose metabolites away from pathways that create Advanced Glycation End-products (AGEs). By mitigating the accumulation of AGEs, which cause protein cross-linking and tissue stiffening, benfotiamine may counter a central mechanism of aging and metabolic disease.

Verdict

A safe, targeted intervention to combat glycation-related aging damage.

Protocol

• Typical doses range from 150-300 mg taken once or twice daily with meals.

Flags

• Generally well-tolerated with no significant known drug interactions at standard doses.
• Benefit may be most pronounced in individuals with impaired glucose metabolism or high sugar intake.