Meta Information

ID:benfotiamine

Name:Benfotiamine

Schema Version:1.5

Alternate Names

• S-benzoylthiamine O-monophosphate

Active Compound

benfotiamine

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement
• eu:food_supplement

Indication

Focus:

• healthspan
• disease_treatment

Description:

Primarily used to manage diabetic complications (neuropathy, nephropathy) by reducing the formation of Advanced Glycation End-products (AGEs), a key driver of aging.

Typical Protocol

• Typical doses range from 150-300 mg taken once or twice daily with meals.

Expected Cost Mean

Low Cost:

10

High Cost:

30

Cost Type:

monthly

Description:

Widely available over-the-counter supplement; not covered by insurance.

Summary

Benfotiamine is a fat-soluble, highly bioavailable derivative of thiamine (Vitamin B1). It works by activating the enzyme transketolase, which shunts harmful glucose metabolites away from pathways that create Advanced Glycation End-products (AGEs). By mitigating the accumulation of AGEs, which cause protein cross-linking and tissue stiffening, benfotiamine may counter a central mechanism of aging and metabolic disease.

Purpose

A vitamin B1 derivative that combats AGEs formation.

Card Summary

A fat-soluble form of Vitamin B1 that helps prevent damage from high blood sugar and the formation of Advanced Glycation End-products (AGEs), a key driver of aging.

Drug Class

null

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Targets a key aging pathway (AGEs), but lacks broad healthspan evidence in healthy humans.

Evidence

Grade:

B

Score:

5.5

Justification:

Strong human RCTs for diabetic complications; evidence for general healthspan is mechanistic or indirect.

Safety

Score:

2.5

Justification:

Excellent safety profile with rare, mild side effects; a derivative of Vitamin B1.

Flags

• Generally well-tolerated with no significant known drug interactions at standard doses.
• Benefit may be most pronounced in individuals with impaired glucose metabolism or high sugar intake.

Verdict

A safe, targeted intervention to combat glycation-related aging damage.

Created

2026-05-06T16:38:58.247342Z

Ai Model

Gemini 2.5 Pro (High)