Apigenin is a plant flavonoid that may support healthspan by inhibiting CD38, an enzyme that depletes NAD+, and by promoting the clearance of senescent cells. The liposomal formulation encapsulates apigenin in lipids to significantly enhance its poor natural bioavailability, potentially leading to more effective systemic concentrations from lower doses.
Verdict
A promising, experimental tool for NAD+ support with a good safety profile.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$30 - $60
Protocol
- Take 25-50 mg once daily, typically in the evening to leverage its mild sedative effects for sleep support.
Flags
- Liposomal delivery significantly increases absorption, potentially potentiating effects and side effects compared to standard forms.
- May cause drowsiness; avoid operating heavy machinery until you know how it affects you.
- Theoretically may interact with sedative medications or drugs metabolized by CYP enzymes.