Meta Information

ID:apigenin-liposomal

Name:Liposomal Apigenin

Schema Version:1.5

Alternate Names

• Bioavailable Apigenin
• Apigenin Phytosome

Active Compound

apigenin

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement
• eu:food_supplement

Indication

Focus:

healthspan

Description:

Targeting cellular senescence, NAD+ preservation via CD38 inhibition, and promoting sleep quality.

Typical Protocol

• Take 25-50 mg once daily, typically in the evening to leverage its mild sedative effects for sleep support.

Expected Cost Mean

Low Cost:

30

High Cost:

60

Cost Type:

monthly

Description:

Higher cost than standard apigenin due to the advanced liposomal delivery system.

Summary

Apigenin is a plant flavonoid that may support healthspan by inhibiting CD38, an enzyme that depletes NAD+, and by promoting the clearance of senescent cells. The liposomal formulation encapsulates apigenin in lipids to significantly enhance its poor natural bioavailability, potentially leading to more effective systemic concentrations from lower doses.

Purpose

A bioavailable flavonoid to inhibit CD38 and support cellular health.

Card Summary

A highly bioavailable form of the flavonoid apigenin, studied for its potential to preserve NAD+ levels, reduce inflammation, and improve sleep quality.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Promising mechanisms (CD38 inhibition) but lacks robust human data for longevity outcomes.

Evidence

Grade:

C

Score:

3

Justification:

Primarily based on pre-clinical (in-vitro, animal) data for core aging mechanisms.

Safety

Score:

3.2

Justification:

Generally recognized as safe, with a good short-term safety profile in humans.

Flags

• Liposomal delivery significantly increases absorption, potentially potentiating effects and side effects compared to standard forms.
• May cause drowsiness; avoid operating heavy machinery until you know how it affects you.
• Theoretically may interact with sedative medications or drugs metabolized by CYP enzymes.

Verdict

A promising, experimental tool for NAD+ support with a good safety profile.

Created

2026-06-12T17:49:04.895546Z

Ai Model

Gemini 2.5 Pro (High)